Project management of preclinical trials / Design and testing of a multi-site COVID-19 LIMS / Concurrent monitoring of 30+ projects at 8+ ABSL3 facilities
Create and organize scientific programs, workshops and conferences / Manage marketing, fundraising, sponsorships and memberships for scientific programs
Next Generation Sequencing (NGS) analysis - mRNA expression and network analysis / CRISPR target design / Transcription factor and pathway analysis / Python, R and Bash programming on Linux systems
General genetic manipulation / Biochemical techniques: Enzyme assay, ELISA, Western, ChIP / Cell Cultures (maintaining & transfection of various cell lines)/ CRISPR-Cas9 gRNA construct and mRNA in vitro transcription / Injecting CRISPR mRNA into zebrafish embryo / Setting up mouse strains and backcrossing / Basic mouse model works - RNA & Protein work with mouse tissues and basic histology
English: Full Professional Proficiency
Korean & Japanese: Native
French: Limited Working Proficiency
Working as a project manager on COVID-19 preclinical experiments. Building the preclinical process platform, executing the project, preparing communication methods, finding solutions to urgent issues, monitoring each preclinical experiment progress from start to finish across 9 teams of 16 PIs at 8 independent labs/facilities. Making reports every week to the Ministry of Science and ICT(MIST) and writing COVID-19 sections for MIST policy reports.
Collecting Korean clinical data from clinicaltrials.gov, MFDS ( https://www.mfds.go.kr/eng ) and CRIS ( http://cris.nih.go.kr ) for building Korean specific clinical trial database for CROs and pharmaceutical companies. Curating and validating clinical trial data and constructing automated bio-curation pipelines to update clinical databases using SNOMED-CT and other disease and medical ontology databases.
Reviewed scientific literature, prepared summaries of consumer genetic testing trends and presented at biweekly meetings as part of a six-person committee preparing an approved and funded grant proposal for a Korean city government. Planning and processing projects related to bioinformatics and genomics grants. Supporting various grant submissions and organizing grant reports. Reviewing manuscripts for lab members and helping graduate students execute and complete ongoing projects and helping graduate students to execute and complete ongoing projects.
Led projects related to the annual Human Genome Meeting (~500 attendees) and four workshops (~100 attendees each). Planning, marketing, handling legal issues, contracts and fundraising for global scientific programs and workshops.
Investigated genes involved in DNA repair/replication process during embryonic development in zebrafish using CRISPR/Cas9 system, especially loss-of-function of DNA repair/replication genes.
Performed microarray and RNA seq experiments (with ribosome profiling) to characterize Mismatch Repair (MMR) proteins, MSH2-MSH6, in baicalein-sensitive MMR-deficient cancer cells.
Inaugural Symposium on U.S.-Korea Collaborative Biomedical Research at NIH
Fellowship supported by the Korea Health Industry Development Institute (KHIDI) of the Korea Ministry of Health and Welfare in cooperation with NIH
Award from Korea Foundation for the Advancement of Science and Creativity(KOFAC) for the first biohacking project at Hacker Space Seoul in South Korea
Fellowship during Master and Ph.D. program supported by Korean government
Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions
Supriya Sinha, Fuyang Li, Diana Villarreal, Jae Hoon Shim, Suhyeon Yoon, Kyungjae Myung, Eun Yong Shim, Sang Eun Lee
PLOS Genetics 2017 April
Ahnak functions as a tumor suppressor via modulation of TGFβ/Smad signaling pathway
Lee IH, Sohn M, Lim HJ, Yoon S, Oh H, Shin S, Shin JH, Oh SH, Kim J, Lee DK, Noh DY, Bae DS5, Seong JK, Bae YS
Oncogene 2014 March; 1–10
miRGator v3.0: a microRNA portal for deep sequencing, expression profiling, and mRNA targeting
Cho SY*, Jang IS*, Jun YK, Yoon S, Ko MJ, Kwon YJ, Choi IJ, Jang HS, Ryu DE, Lee BW, Kim VN, Kim WK, Lee SH
Nucleic Acids Res. 2013 Jan; 41(Database issue): D252-257.
ChimerDB 2.0--a knowledgebase for fusion genes updated.
Kim P*, Yoon S*, Kim N*, Lee S*, Ko M, Lee H, Kang H, Kim J, Lee S.
Nucleic Acids Res. 2010 Jan; 38(Database issue): D81-85.
Regulation of megakaryocytic differentiation of K562 cells by FosB, a member of the Fos family of AP-1 transcription factors.
Limb JK*, Yoon S, Lee KE, Kim BH, Lee S, Bae YS, Jhon GJ, Kim J.
Cell Mol Life Sci. 2009 Jun; 66(11-12):1962-73.
Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complex.
Lee IH*, Lim HJ*, Yoon S, Seong JK, Bae DS, Rhee SG, Bae YS.
J Biol Chem. 2008 Mar 7; 283(10):6312-20.
Available upon request